Host genetic factors in malaria
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چکیده
It is estimated that each 25%-30% in the variability in the incidence of malaria can be attributed to genetic and environmental factors, respectively. In various study designs on the different types of manifestation of Plasmodium falciparum infection, associations between genetic polymorphisms and malaria are examined. The selection of polymorphisms under study follows hypotheses on the role of e.g. immune receptors in the pathophysiology of malaria. Beyond epidemiological aspects of influencing the risks of infection, disease, and fatality, functional analyses are increasingly focused on. These examinations aim at an improved understanding of the epidemiological and functional relationships between protective or disposing factors and disease to ultimately generate starting-points for therapeutical or preventive measures.
منابع مشابه
Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes.
There is growing evidence for human genetic factors controlling the outcome of malaria infection, while molecular basis of this genetic control is still poorly understood. Case-control and family-based studies have been carried out to identify genes underlying host susceptibility to malarial infection. Parasitemia and mild malaria have been genetically linked to human chromosomes 5q31-q33 and 6...
متن کاملCALL FOR PAPERS Updates on Mapping Quantitative Trait Loci Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes
Hernandez-Valladares M, Rihet P, Iraqi FA. Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes. Physiol Genomics 46: 1–16, 2014. First published October 29, 2013; doi:10.1152/physiolgenomics.00044.2013.—There is growing evidence for human genetic factors controlling the outcome of malaria infection, while molecular basis of this genetic ...
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